anti-VEGFR2 monoclonal antibody MSB0254

{
  "id": "MLC-T-ONC-011176",
  "term": "anti-VEGFR2 monoclonal antibody MSB0254",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against human vascular endothelial growth factor receptor 2 (VEGFR-2; VEGFR2) with potential anti-angiogenesis and antineoplastic activities. Upon administration, anti-VEGFR2 monoclonal antibody MSB0254 specifically binds to and inhibits VEGFR2, which may inhibit tumor angiogenesis and tumor cell proliferation. VEGFR2, a tyrosine-protein kinase that plays an essential role in angiogenesis and the proliferation, survival, migration and differentiation of endothelial cells, is overexpressed in certain tumor types.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-vegfr2-monoclonal-antibody-msb0254/"
}