anti-VEGFR-2 monoclonal antibody AK109

{
  "id": "MLC-T-ONC-011174",
  "term": "anti-VEGFR-2 monoclonal antibody AK109",
  "field": "Oncology and biomedicine",
  "definition": "A human monoclonal antibody directed against human vascular endothelial growth factor receptor 2 (VEGFR-2; VEGFR2), with potential anti-angiogenesis and antineoplastic activities. Upon administration, anti-VEGFR-2 monoclonal antibody AK109 specifically binds to and inhibits VEGFR-2 on vascular endothelial cells, which may inhibit tumor angiogenesis and tumor cell proliferation. VEGFR-2, a tyrosine-protein kinase that plays an essential role in angiogenesis and the proliferation, survival, migration and differentiation of endothelial cells, is overexpressed in certain tumor types.",
  "synonyms": [
    "anti-VEGFR2 monoclonal antibody AK109"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-vegfr-2-monoclonal-antibody-ak109/"
}