B-Raf/VEGFR-2 inhibitor RAF265

{
  "id": "MLC-T-ONC-012101",
  "term": "B-Raf/VEGFR-2 inhibitor RAF265",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable small molecule with potential antineoplastic activity. CHIR-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/b-raf-vegfr-2-inhibitor-raf265/"
}