naporafenib

{
  "id": "MLC-T-ONC-015436",
  "term": "naporafenib",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of all members of the serine/threonine protein kinase Raf family, with potential antineoplastic activity. Upon administration, naporafenib binds to Raf proteins and inhibits Raf-mediated signal transduction pathways. This inhibits proliferation of Raf-overexpressing tumor cells. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types. They play key roles in tumor cell proliferation and survival.",
  "synonyms": [
    "Raf family kinase inhibitor LXH254",
    "pan-RAF inhibitor LXH254",
    "pan-RAF kinase inhibitor LXH254"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/naporafenib/"
}