pan-RAF inhibitor JZP815

{
  "id": "MLC-T-ONC-015810",
  "term": "pan-RAF inhibitor JZP815",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of all members of the serine/threonine protein kinase Raf family, including A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon oral administration, pan-RAF inhibitor JZP815 selectively binds to and inhibits the activity of wild-type and mutated forms of Raf, including B-Raf mutations, and B-Raf fusions. This prevents the activation of Raf-mediated signal transduction pathways, which may inhibit tumor cell growth. Oncogenic mutations in Raf plays a key role in the overactivation of the Ras-mitogen-activated protein kinase (MAPK) pathway and drives tumor cell proliferation and survival.",
  "synonyms": [
    "RAF inhibitor JZP815"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pan-raf-inhibitor-jzp815/"
}