pan-PIM kinase inhibitor GDC-0570

{
  "id": "MLC-T-ONC-015809",
  "term": "pan-PIM kinase inhibitor GDC-0570",
  "field": "Oncology and biomedicine",
  "definition": "An orally available small molecule pan-inhibitor of the PIM serine/threonine kinase family, with potential antineoplastic activity. Upon oral administration, pan-PIM kinase inhibitor GDC-0570 binds to and prevents the activation of the three PIM family kinases, PIM1, PIM2 and PIM3. This prevents the activation of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress PIMs. PIMs, constitutively active proto-oncogenic serine/threonine kinases upregulated in various types of cancers, play key roles in tumor cell proliferation and survival.",
  "synonyms": [
    "pan-PIM kinase inhibitor NB004"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pan-pim-kinase-inhibitor-gdc-0570/"
}