PIM kinase inhibitor TP-3654

{
  "id": "MLC-T-ONC-016072",
  "term": "PIM kinase inhibitor TP-3654",
  "field": "Oncology and biomedicine",
  "definition": "An orally available, second-generation and selective ATP-competitive inhibitor of proviral integration site for Moloney murine leukemia virus (PIM) kinases, with potential antineoplastic activity. Upon oral administration, PIM kinase inhibitor TP-3654 selectively binds to and prevents the activation of the PIM kinases. This prevents the activation of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress PIM. PIMs, constitutively active proto-oncogenic serine/threonine kinases, are upregulated in various types of cancers and play key roles in tumor cell proliferation and survival.",
  "synonyms": [
    "PIM inhibitor TP-3654"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pim-kinase-inhibitor-tp-3654/"
}