Aurora B/C kinase inhibitor GSK1070916A

{
  "id": "MLC-T-ONC-000829",
  "term": "Aurora B/C kinase inhibitor GSK1070916A",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of some types of cancer. It blocks certain enzymes (Aurora kinases) involved in cell division and may kill cancer cells. It is a type of serine/threonine protein kinase inhibitor. Also called GSK1070916A.",
    "An ATP-competitive inhibitor of the serine/threonine kinases Aurora B and C with potential antineoplastic activity. Aurora B/C kinase inhibitor GSK1070916A binds to and inhibits the activity of Aurora kinases B and C, which may result in inhibition of cellular division and a decrease in the proliferation of tumor cells that overexpress the Aurora kinases B and C. Aurora kinases play essential roles in mitotic checkpoint control during mitosis, and are overexpressed by a wide variety of cancer cell types."
  ],
  "synonyms": [
    "GSK1070916A"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/aurora-b-c-kinase-inhibitor-gsk1070916a/"
}