Aurora B Serine/Threonine Kinase Inhibitor TAK-901

{
  "id": "MLC-T-ONC-011303",
  "term": "Aurora B Serine/Threonine Kinase Inhibitor TAK-901",
  "field": "Oncology and biomedicine",
  "definition": "A small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Aurora B kinase inhibitor TAK-901 binds to and inhibits the activity of Aurora B, which may result in a decrease in the proliferation of tumor cells that overexpress Aurora B. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere; the segregation of sister chromatids to each daughter cell; and the separation of daughter cells during cytokinesis. This serine/threonine kinase may be amplified and overexpressed by a variety of cancer cell types.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/aurora-b-serine-threonine-kinase-inhibitor-tak-901/"
}