aurora A kinase inhibitor VIC-1911

{
  "id": "MLC-T-ONC-011301",
  "term": "aurora A kinase inhibitor VIC-1911",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the serine/threonine protein kinase aurora A, with potential antimitotic and antineoplastic activities. Upon intravenous administration, aurora A kinase inhibitor VIC-1911 binds to and inhibits aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, inhibition of cell division and the induction of apoptosis in cells overexpressing aurora A kinase. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis; it plays an essential role in the regulation of spindle assembly. Aurora kinase A is overexpressed in a wide variety of cancers.",
  "synonyms": [
    "TAS-2104",
    "aurora A kinase inhibitor TAS-119"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/aurora-a-kinase-inhibitor-vic-1911/"
}