Alisertib sodium

{
  "id": "MLC-T-ONC-000376",
  "term": "Alisertib sodium",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that binds to a protein called Aurora A kinase and blocks its activity. Aurora A kinase plays an important role in cell division and may be found on some cancer cells. Blocking this protein may help keep cancer cells from growing and may kill them. Alisertib sodium is being studied in the treatment of some types of cancer. It is a type of protein kinase inhibitor.",
    "The sodium salt form of alisertib, a second-generation, orally bioavailable, selective inhibitor of the serine/threonine protein kinase Aurora A kinase, with potential antineoplastic activity. Upon oral administration, alisertib targets, binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation in susceptible cancer cells. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers and plays a key role in cancer cell proliferation."
  ],
  "synonyms": [
    "MLN8237 sodium",
    "MLN8237-004"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/alisertib-sodium/"
}