Aurora kinase inhibitor AMG 900

{
  "id": "MLC-T-ONC-011304",
  "term": "Aurora kinase inhibitor AMG 900",
  "field": "Oncology and biomedicine",
  "definition": "A small-molecule inhibitor of Aurora kinases A, B and C with potential antineoplastic activity. Aurora kinase inhibitor AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis and are overexpressed by a wide variety of cancer cell types.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/aurora-kinase-inhibitor-amg-900/"
}