Pim kinase inhibitor SGI-1776

{
  "id": "MLC-T-ONC-016071",
  "term": "Pim kinase inhibitor SGI-1776",
  "field": "Oncology and biomedicine",
  "definition": "A small-molecule pan-Pim protein kinase inhibitor with potential antineoplastic activity. Pim kinase inhibitor SGI-1776 binds to and inhibits the activities of Pim-1, -2 and -3, serine-threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pim-kinase-inhibitor-sgi-1776/"
}