pan-Raf inhibitor KIN-2787

{
  "id": "MLC-T-ONC-015811",
  "term": "pan-Raf inhibitor KIN-2787",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of class I, II, and III B-Raf (BRAF) protein kinases, with potential antineoplastic activity. Upon administration, pan-Raf inhibitor KIN-2787 binds to and inhibits Class I, Class II, or Class III B-Raf mutations. This prevents B-Raf-mediated signal transduction pathways, which may lead to an inhibition of tumor growth in B-Raf mutant cells. B-Raf protein kinases play a key role in the RAF/MEK/ERK signaling pathway, which is often deregulated and mutated in human cancers, and plays a key role in tumor cell proliferation and survival.",
  "synonyms": [
    "B-Raf inhibitor KIN-2787"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pan-raf-inhibitor-kin-2787/"
}