Raf kinase inhibitor XL281

{
  "id": "MLC-T-ONC-016351",
  "term": "Raf kinase inhibitor XL281",
  "field": "Oncology and biomedicine",
  "definition": "An orally active, small molecule with potential antineoplastic activity. XL281 specifically inhibits RAF kinases, located downstream from RAS in the RAS/RAF/MEK/ERK kinase signaling pathway, which may result in reduced proliferation of tumor cells. RAS mutations may result in constitutive activation of the RAS/RAF/MEK/ERK kinase signaling pathway, and have been found to occur frequently in human tumors.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/raf-kinase-inhibitor-xl281/"
}