pan-HER/VEGFR2 receptor tyrosine kinase inhibitor BMS-690514

{
  "id": "MLC-T-ONC-015794",
  "term": "pan-HER/VEGFR2 receptor tyrosine kinase inhibitor BMS-690514",
  "field": "Oncology and biomedicine",
  "definition": "A pyrrolotriazine-based compound and a pan inhibitor of receptor tyrosine kinases with potential antineoplastic activity. Pan HER/VEGFR2 receptor tyrosine kinase inhibitor BMS-690514 binds to human epidermal growth factor receptors (EGFR) 1, 2 and 4 (HER1, HER2 and HER4) and vascular endothelial growth factor receptor 1, 2 and 3 (VEGFR-1, -2 and -3), all of which are frequently overexpressed by a variety of tumor types. Binding of this agent to these receptors may result in the inhibition of tumor cell proliferation; the inhibition of endothelial cell migration and proliferation and angiogenesis; and tumor cell death.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pan-her-vegfr2-receptor-tyrosine-kinase-inhibitor-bms-690514/"
}