parsatuzumab

{
  "id": "MLC-T-ONC-015853",
  "term": "parsatuzumab",
  "field": "Oncology and biomedicine",
  "definition": "A humanized IgG1 monoclonal antibody directed against the epidermal growth factor-like domain multiple 7 (EGFL7) with potential antineoplastic activity. Parsatuzumab binds to EGFL7, thereby preventing the activities of EGFL7 on endothelial cells and inhibiting the survival and migration of endothelial cells during angiogenesis. EGFL7, a vascular-restricted extracellular matrix protein which is upregulated during angiogenesis and which regulates vascular development, may be overexpressed on the cell surfaces of various solid tumor cell types.",
  "synonyms": [
    "anti-epidermal growth factor-like domain 7 monoclonal antibody MEGF0444A"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/parsatuzumab/"
}