anti-TROP-2/MMAE antibody-drug conjugate LCB84

{
  "id": "MLC-T-ONC-011163",
  "term": "anti-TROP-2/MMAE antibody-drug conjugate LCB84",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of Hu2G10, a humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1), conjugated via a beta-glucuronidase-cleavable linker to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule disrupting agent, with potential antineoplastic activity. Upon administration of anti-TROP-2/MMAE ADC LCB84, the anti-TROP-2 antibody targets and binds to TROP-2 expressed on tumor cells. Upon binding and internalization, MMAE is released upon cleavage by the cancer-associated lysosomal enzyme beta-glucuronidase. MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis. This induces cell death in TROP-2-expressing cancer cells. TROP-2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival.",
  "synonyms": [
    "anti-TROP-2/MMAE ADC LCB84"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-trop-2-mmae-antibody-drug-conjugate-lcb84/"
}