anti-TROP-2 antibody-drug conjugate PBI-410

{
  "id": "MLC-T-ONC-011158",
  "term": "anti-TROP-2 antibody-drug conjugate PBI-410",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; tumor-associated calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) site-specifically conjugated to a camptothecin analog via a cleavable linker, with potential antineoplastic activity. Upon administration of the anti-TROP-2 ADC PBI-410, the anti-TROP-2 antibody targets and binds to TROP-2 expressed on tumor cells. Upon binding and internalization, the camptothecin analog is released, and inhibits DNA topoisomerase-1 activity, thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation of TROP-2-expressing tumor cells. TROP-2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival.",
  "synonyms": [
    "anti-TROP-2 ADC PBI-410",
    "anti-TROP-2/TOP1i ADC PBI-410"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-trop-2-antibody-drug-conjugate-pbi-410/"
}