anti-uPARAP ADC ADCE-D01

{
  "id": "MLC-T-ONC-011169",
  "term": "anti-uPARAP ADC ADCE-D01",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of AB-004, a humanized monoclonal antibody directed against urokinase plasminogen activator receptor-associated protein (uPARAP; endocytic receptor 180; Endo180; C-type mannose receptor 2) conjugated, via a protease-cleavable tetra-peptide linker, to the topoisomerase-1 inhibitor (TOP1i) P1021, with potential antineoplastic activity. Upon administration of anti-uPARAP ADC ADCE-D01, AB-004 targets and binds to uPARAP-expressing tumor cells. Upon binding, internalization and linker cleavage, P1021 is released, and inhibits DNA topoisomerase-1 activity, thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation of uPARAP-expressing tumor cells. uPARAP, a recycling endocytic receptor involved in collagen homeostasis and turnover, is overexpressed on various tumor cell types while its expression is limited in healthy tissues.",
  "synonyms": [
    "ADC ADCE-D01",
    "anti-uPARAP/P1021 ADC ADCE-D01",
    "antibody-drug conjugate ADCE-D01",
    "uPARAP-targeting ADC ADCE-D01"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-uparap-adc-adce-d01/"
}