anti-VEGF/ANG2 nanobody BI 836880

{
  "id": "MLC-T-ONC-011172",
  "term": "anti-VEGF/ANG2 nanobody BI 836880",
  "field": "Oncology and biomedicine",
  "definition": "A nanobody directed against angiopoietin-2 (Ang2; ANGPT2)- and vascular endothelial growth factor (VEGF)-derived peptides, with potential antiangiogenic and antineoplastic activities. Anti-VEGF/ANG2 nanobody BI 836880 binds to Ang2 and VEGF and inhibits receptor binding; this prevents Ang2- and VEGF-mediated signaling and inhibits both tumor angiogenesis and tumor cell proliferation. Both VEGF and Ang2 are upregulated in a variety of cancer cell types and each plays a crucial role in angiogenesis. The nanobody is based on functional fragments of single-chain antibodies.",
  "synonyms": [
    "bi-specific anti-VEGF/Ang2 nanobody BI 836880",
    "anti-VEGF/ANG2 BI 836880"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-vegf-ang2-nanobody-bi-836880/"
}