anti-VEGF monoclonal antibody hPV19

{
  "id": "MLC-T-ONC-011171",
  "term": "anti-VEGF monoclonal antibody hPV19",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against human vascular endothelial growth factor (VEGF), with potential anti-angiogenic and antineoplastic activities. Upon administration, anti-VEGF monoclonal antibody hPV19 targets and binds to VEGFR at a unique binding site and inhibits VEGF binding to its receptors, VEGFR1 and VEGFR2, thereby preventing VEGF/VEGFR-mediated signaling. This prevents the growth and maintenance of tumor blood vessels. This decreases nutrient supply to tumor cells, resulting in tumor cell death. Increased VEGF/VEGFR signaling is associated with increased invasiveness and decreased survival.",
  "synonyms": [
    "anti-VEGF MAb hPV19",
    "MAb hPV19"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-vegf-monoclonal-antibody-hpv19/"
}