antibody-drug conjugate anti-TIM-1-vcMMAE CDX-014

{
  "id": "MLC-T-ONC-010179",
  "term": "antibody-drug conjugate anti-TIM-1-vcMMAE CDX-014",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody-drug conjugate (ADC) comprised of human immunoglobulin G1 (IgG1) clone CR014, which targets the extracellular domain of T-cell immunoglobulin mucin-1 (TIM-1; HAVCR1), that is linked, via a valine-citrulline (VC) peptide linker, to the potent cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration of ADC anti-TIM-1-vcMMAE CDX-014, the monoclonal antibody moiety targets and binds to TIM-1. Upon internalization and proteolytic cleavage, MMAE is released into the cytosol of TIM-1-expressing tumor cells, binds to tubulin, and inhibits microtubule polymerization, which induces both G2/M phase arrest and tumor cell apoptosis. TIM-1 is upregulated in a variety of cancer cell types while only minimally expressed in healthy tissue. The linkage system in CDX-014 is highly stable in plasma, resulting in increased specificity and cytotoxic efficacy towards TIM-1-positive cells.",
  "synonyms": [
    "CR014-vcMMAE",
    "antibody-drug conjugate CDX-014",
    "ADC CDX-014",
    "CR014-vc-MMAE",
    "ADC anti-TIM-1-vcMMAE CDX-014"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/antibody-drug-conjugate-anti-tim-1-vcmmae-cdx-014/"
}