autologous anti-PSMA gene-modified T lymphocytes

{
  "id": "MLC-T-ONC-011495",
  "term": "autologous anti-PSMA gene-modified T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous prostate specific membrane antigen (PSMA) gene-modified T lymphocytes with potential antineoplastic activity. Human autologous T lymphocytes are isolated and transduced ex vivo with a retrovirus encoding a chimeric immune receptor (CIR) consisting of an antibody fragment against PSMA fused with signaling domains of the T cell. Upon reintroduction into the patient, autologous anti-PSMA gene-modified T cells bind to PSMA-expressing prostate cancer cells, which may result in specific cytotoxic T-lymphocyte (CTL) tumor cell killing.",
  "synonyms": [
    "autologous anti-prostate-specific membrane antigen gene-modified T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-psma-gene-modified-t-lymphocytes/"
}