autologous CD34-positive BCL11A-disrupted hematopoietic progenitor cells ST-400

{
  "id": "MLC-T-ONC-011555",
  "term": "autologous CD34-positive BCL11A-disrupted hematopoietic progenitor cells ST-400",
  "field": "Oncology and biomedicine",
  "definition": "A population of autologous CD34-positive, B-cell lymphoma/leukemia 11A (BCL11A)-disrupted hematopoietic progenitor cells (HPCs) that may be used for bone marrow autotransplantation. CD34-positive HPCs are isolated from human blood upon apheresis and are genetically modified in vitro using a proprietary zinc finger nuclease (ZFN) technology to specifically disrupt the transcriptional enhancer sequence for the BCL11A gene. Upon infusion into the patient following conditioning chemotherapy, the autologous CD34-positive BCL11A-disrupted HPCs ST-400 can populate the bone marrow and differentiate into a variety of blood cell types including lymphoid cells, myeloid cells and erythroblasts. BCL11A is a suppressor of fetal hemoglobin (HbF) expression. Therefore, disruption of the BCL11A enhancer decreases the expression of BCL11A and stimulates the expression of HbF in erythrocytes that differentiate from ST-400. HbF may compensate for reduced or absent expression of adult hemoglobin in patients, including those with transfusion-dependent beta-thalassemia.",
  "synonyms": [
    "autologous BCL11A-disrupted hematopoietic progenitor cells ST-400",
    "autologous BCL11A-disrupted HPCs ST-400",
    "autologous CD34-positive BCL11A-disrupted HPCs ST-400"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cd34-positive-bcl11a-disrupted-hematopoietic-progenitor-cells-st-400/"
}