Autologous cultured acute myeloid leukemia-specific cytotoxic T lymphocytes

{
  "id": "MLC-T-ONC-011589",
  "term": "Autologous cultured acute myeloid leukemia-specific cytotoxic T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of cytotoxic, autologous acute myelogenous leukemia (AML)-reactive T lymphocytes (CTL), with potential immunomodulating and antineoplastic activities. The autologous cultured AML-specific CTLs are prepared using a specific AML-CTL culture method. Autologous peripheral blood lymphocytes are taken from an AML patient and the autologous AML blasts are treated with granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4), both of which promote ex vivo differentiation of AML blasts into dendritic cells (DCs). In the same culture, T cells are treated and activated by low-dose interleukin 2 (IL-2), and expanded using anti-CD3. This results in cultured AML-reactive CTLs which are administered back into the patient after autologous hematopoietic stem cell transplant (AHSCT). The autologous cultured AML-specific CTLs may eradicate residual AML cells.",
  "synonyms": [
    "autologous AML-specific CTL",
    "autologous AML-reactive cultured CTLs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cultured-acute-myeloid-leukemia-specific-cytotoxic-t-lymphocytes/"
}