AML mRNA positive lysate loaded autologous dendritic cell vaccine

{
  "id": "MLC-T-ONC-010037",
  "term": "AML mRNA positive lysate loaded autologous dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of autologous dendritic cells loaded with separate preparations of acute myelogenous leukemia (AML) cell lysate and AML-specific messenger RNA (mRNA) with potential immunostimulatory and antineoplastic activities. Upon administration, AML mRNA plus lysate loaded autologous dendritic cell vaccine may elicit a potent cytotoxic T-cell (CTL) response against AML cells, resulting in tumor cell death. Autologous dendritic cells doubly-loaded with AML cell lysate and AML-specific mRNA may elicit superior primary, recall, and effector lytic immune responses compared to autologous dendritic cells loaded with tumor lysate or tumor mRNA alone.",
  "synonyms": [
    "acute myelogenous leukemia mRNA plus lysate loaded autologous dendritic cell vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/aml-mrna-positive-lysate-loaded-autologous-dendritic-cell-vaccine/"
}