MLchartDataset catalogue

azaribine

Term · Oncology and biomedicine · MLC-T-ONC-011843

The triacetate salt of azauridine, a synthetic triazine nucleoside derivative possessing antineoplastic and anti-psoriatic activity. After metabolism to 6-azauridine-5-prime monophosphate, 6-Azauridine inhibits de novo pyrimidine biosynthesis and its 5-prime triphosphate metabolite gets incorporated into RNA, thereby preventing RNA synthesis.

Table 1. Record
IdentifierMLC-T-ONC-011843
FieldOncology and biomedicine
Synonyms6-azauridine triacetate; azauridine triacetate; triazure
ReferencesNational Cancer Institute Thesaurus (CC BY 4.0)
Record as JSON
{
  "id": "MLC-T-ONC-011843",
  "term": "azaribine",
  "field": "Oncology and biomedicine",
  "definition": "The triacetate salt of azauridine, a synthetic triazine nucleoside derivative possessing antineoplastic and anti-psoriatic activity. After metabolism to 6-azauridine-5-prime monophosphate, 6-Azauridine inhibits de novo pyrimidine biosynthesis and its 5-prime triphosphate metabolite gets incorporated into RNA, thereby preventing RNA synthesis.",
  "synonyms": [
    "6-azauridine triacetate",
    "azauridine triacetate",
    "triazure"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/azaribine/"
}

Record 3,210 of 17,721 in Oncology and biomedicine terminology (MLC-0111). Request the full dataset.