azaribine
Term · Oncology and biomedicine · MLC-T-ONC-011843
The triacetate salt of azauridine, a synthetic triazine nucleoside derivative possessing antineoplastic and anti-psoriatic activity. After metabolism to 6-azauridine-5-prime monophosphate, 6-Azauridine inhibits de novo pyrimidine biosynthesis and its 5-prime triphosphate metabolite gets incorporated into RNA, thereby preventing RNA synthesis.
| Identifier | MLC-T-ONC-011843 |
|---|---|
| Field | Oncology and biomedicine |
| Synonyms | 6-azauridine triacetate; azauridine triacetate; triazure |
| References | National Cancer Institute Thesaurus (CC BY 4.0) |
Record as JSON
{
"id": "MLC-T-ONC-011843",
"term": "azaribine",
"field": "Oncology and biomedicine",
"definition": "The triacetate salt of azauridine, a synthetic triazine nucleoside derivative possessing antineoplastic and anti-psoriatic activity. After metabolism to 6-azauridine-5-prime monophosphate, 6-Azauridine inhibits de novo pyrimidine biosynthesis and its 5-prime triphosphate metabolite gets incorporated into RNA, thereby preventing RNA synthesis.",
"synonyms": [
"6-azauridine triacetate",
"azauridine triacetate",
"triazure"
],
"references": [
"National Cancer Institute Thesaurus"
],
"url": "https://mlchart.com/terminology/oncology/azaribine/"
}
Record 3,210 of 17,721 in Oncology and biomedicine terminology (MLC-0111). Request the full dataset.