pyrazofurin

{
  "id": "MLC-T-ONC-016306",
  "term": "pyrazofurin",
  "field": "Oncology and biomedicine",
  "definition": "A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication.",
  "synonyms": [
    "pyrazomycin",
    "beta-pyrazomycin",
    "compound 47599",
    "pirazofurin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pyrazofurin/"
}