Benralizumab

{
  "id": "MLC-T-ONC-011953",
  "term": "Benralizumab",
  "field": "Oncology and biomedicine",
  "definition": "An afucosylated, humanized monoclonal antibody against the alpha chain of the interleukin-5 receptor (IL-5Ra), with potential anti-asthmatic activity. Upon administration, benralizumab binds to IL-5Ra and elicits an antibody-directed cell cytotoxicity (ADCC) against IL-5Ra-expressing cells. This induces apoptosis in IL-5Ra-expressing cells and may reduce asthmatic episodes. IL-5Ra, expressed on both eosinophils and basophils, plays a key role in asthma.",
  "synonyms": [
    "anti-CD125 humanized monoclonal antibody, IgG1-kappa"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/benralizumab/"
}