stapokibart

{
  "id": "MLC-T-ONC-016863",
  "term": "stapokibart",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant humanized monoclonal antibody directed against the alpha chain of the interleukin-4 receptor (IL-4RA; IL-4R alpha), with potential anti-inflammatory and immunomodulatory activities. Upon administration, stapokibart selectively binds to IL-4RA. This disrupts IL-4/IL-13 signaling and prevents the activation of downstream pathways that mediate type 2 inflammation. IL-4 and IL-13 receptors are present on the surface of numerous cells involved in the pathophysiology of type-2 helper T-cell (Th2) allergic responses, including B lymphocytes, eosinophils, dendritic cells (DCs), monocytes, macrophages, basophils, keratinocytes, bronchial epithelial cells, endothelial cells, fibroblasts, and airway smooth muscle cells.",
  "synonyms": [
    "anti-IL-4RA monoclonal antibody CM310",
    "anti-IL-4 receptor alpha monoclonal antibody CM310",
    "anti-interleukin-4 receptor subunit alpha monoclonal antibody CM310"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/stapokibart/"
}