bispecific antibody MDX-H210

{
  "id": "MLC-T-ONC-012040",
  "term": "bispecific antibody MDX-H210",
  "field": "Oncology and biomedicine",
  "definition": "A humanized bivalent antibody directed against both cytotoxic effector cells expressing Fc gamma receptor type I (Fc gammaRI, or CD64) and HER2/neu-overexpressing tumor cells with potential antineoplastic activity. Bispecific antibody MDX-H210 was constructed by chemically linking Fab' fragments of the anti-HER2/neu-specific monoclonal antibody 520C9 and the Fab' fragments of the anti-Fc gammaRI-specific monoclonal antibody H22. This agent selectively binds to both HER2/neu-expressing tumor cells and Fc gammaRI-expressing cytotoxic effector cells, which may trigger antibody-dependent cell-mediated cytotoxicity (ADCC) and cell lysis of HER2/neu-expressing tumor cells. While HER2/neu is overexpressed in a variety of epithelial malignancies, expression of Fc gammaRI is primarily found in cytotoxic immune cells, including monocytes, macrophages, and cytokine-activated polymorphonuclear (PMN) cells.",
  "synonyms": [
    "520C9x22 bispecific antibody",
    "520C9xH22 bispecific antibody",
    "antibody, bispecific 520C9xH22",
    "bispecific antibody 520C9 x H22",
    "bispecific antibody MDXH210",
    "BsAb 520C9x22",
    "BsAb 520C9xH22"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bispecific-antibody-mdx-h210/"
}