Bleomycin sulfate

{
  "id": "MLC-T-ONC-001106",
  "term": "Bleomycin sulfate",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug that comes from the bacterium Streptomyces verticillus and is used alone or with other drugs to treat many types of cancer, including Hodgkin lymphoma, non-Hodgkin lymphoma, testicular cancer, malignant pleural effusion, and squamous cell carcinoma of the cervix, head and neck, penis, and vulva. It is also being studied in the treatment of other types of cancer. Bleomycin sulfate damages the cell’s DNA and may kill cancer cells. It is a type of antineoplastic antibiotic. Bleomycin is the active ingredient of bleomycin sulfate.",
    "A mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation."
  ],
  "synonyms": [
    "bleomycin sulfas",
    "bleomycin sulphate",
    "bleomycini sulfas",
    "blexane"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bleomycin-sulfate/"
}