peplomycin

{
  "id": "MLC-T-ONC-015953",
  "term": "peplomycin",
  "field": "Oncology and biomedicine",
  "definition": "A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity.",
  "abbreviation": "PEP",
  "synonyms": [
    "pepleomycin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/peplomycin/"
}