porfiromycin

{
  "id": "MLC-T-ONC-006823",
  "term": "porfiromycin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anticancer antibiotics.",
    "An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells."
  ],
  "synonyms": [
    "methyl mitomycin C",
    "methyl mitomycin",
    "Methylmitomycin",
    "porfiromycine",
    "porphyromycin"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/porfiromycin/"
}