MLchartDataset catalogue

KW-2149

Term · Oncology and biomedicine · MLC-T-ONC-014683

A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C. Activated by serum and glutathione, KW-2149 causes interstrand DNA cross-links and DNA-protein cross-links, resulting in single-strand DNA breaks and inhibition of DNA synthesis.

Table 1. Record
IdentifierMLC-T-ONC-014683
FieldOncology and biomedicine
ReferencesNational Cancer Institute Thesaurus (CC BY 4.0)
Record as JSON 
{
  "id": "MLC-T-ONC-014683",
  "term": "KW-2149",
  "field": "Oncology and biomedicine",
  "definition": "A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C. Activated by serum and glutathione, KW-2149 causes interstrand DNA cross-links and DNA-protein cross-links, resulting in single-strand DNA breaks and inhibition of DNA synthesis.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/kw-2149/"
}

Record 9,847 of 17,721 in Oncology and biomedicine terminology (MLC-0111). Request the full dataset.