Cisplatin micelle formulation HA132

{
  "id": "MLC-T-ONC-012611",
  "term": "Cisplatin micelle formulation HA132",
  "field": "Oncology and biomedicine",
  "definition": "A micelle formulation containing the inorganic platinum agent cisplatin, with potential antineoplastic activity. Upon administration, cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and growth inhibition of tumor cells.",
  "synonyms": [
    "cisplatin micelle HA132"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cisplatin-micelle-formulation-ha132/"
}