carboplatin

{
  "id": "MLC-T-ONC-001416",
  "term": "carboplatin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat advanced ovarian cancer that has never been treated or has come back after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Carboplatin works in a way similar to the anticancer drug cisplatin and causes fewer side effects. It damages the cell’s DNA and may kill cancer cells. Carboplatin is a type of platinum compound.",
    "A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic."
  ],
  "abbreviation": "CBDCA",
  "synonyms": [
    "Carboplatin Hexal",
    "Carboplatino",
    "carboplatinum"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carboplatin/"
}