Lobaplatin

{
  "id": "MLC-T-ONC-004894",
  "term": "Lobaplatin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that contains the metal platinum and may kill cancer cells by damaging their DNA and stopping them from dividing. It is a type of alkylating agent.",
    "A third-generation, water-soluble platinum compound with potential antineoplastic activity. Lobaplatin forms highly reactive, charged, platinum complexes that bind to nucleophilic groups such as GC- and AG-rich sites in DNA, inducing intrastrand DNA cross-links. These cross-links will ultimately result in induction of apoptosis and cell growth inhibition. Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance."
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lobaplatin/"
}