platinum acetylacetonate-titanium dioxide nanoparticles

{
  "id": "MLC-T-ONC-016110",
  "term": "platinum acetylacetonate-titanium dioxide nanoparticles",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of platinum acetylacetonate supported by sol-gel technology functionalized titania, with potential antineoplastic activity. Upon intravenous administration, the platinum moiety forms complexes with nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links, resulting in apoptosis and cell growth inhibition. Compared to platinum alone, the nanoparticle formulation allows increased delivery of platinum to the tumor site, thereby increasing efficacy while reducing systemic toxicity.",
  "synonyms": [
    "sol-gel NPt nanomaterial",
    "sol-gel NPt nanoparticles",
    "NPt nanomaterial",
    "NPt nanoparticles",
    "Pt(acac)2/titanium dioxide",
    "Pt(acac)2/F-TiO2",
    "platinum-titania nanoparticles",
    "platinum acetylacetonate nanomaterial",
    "Pt(acac)2/F-TiO2 nanoparticles"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/platinum-acetylacetonate-titanium-dioxide-nanoparticles/"
}