Nedaplatin

{
  "id": "MLC-T-ONC-015459",
  "term": "Nedaplatin",
  "field": "Oncology and biomedicine",
  "definition": "A second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.",
  "synonyms": [
    "nedaplat"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nedaplatin/"
}