cisplatin

{
  "id": "MLC-T-ONC-001788",
  "term": "cisplatin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used alone or with other drugs to treat certain types of bladder cancer, ovarian cancer, and testicular cancer. It is also being studied in the treatment of other types of cancer. Cisplatin damages the cell's DNA and may kill cancer cells. It is a type of platinum compound. The brand name Platinol has been taken off the market and is no longer available.",
    "An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition."
  ],
  "abbreviation": "CDDP",
  "synonyms": [
    "DDP",
    "cis-platinum",
    "cis-platinum II",
    "cis-diamminedichloro platinum (II)",
    "cis-diamminedichloroplatinum",
    "Cis-dichloroammine Platinum (II)",
    "cis-platinous diamine dichloride",
    "cis-platinum II diamine dichloride",
    "cis-diamminedichloridoplatinum",
    "Cismaplat",
    "Cisplatina",
    "Cysplatyna",
    "Peyrone's Chloride",
    "Peyrone's Salt",
    "Platinoxan",
    "platinum diamminodichloride",
    "platinum"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cisplatin/"
}