mitomycin

{
  "id": "MLC-T-ONC-005418",
  "term": "mitomycin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug that comes from the bacterium Streptomyces and is used alone under the brand name Jelmyto to treat adults with a certain type of urothelial cancer and with other drugs to treat certain types of stomach cancer and pancreatic cancer. It is also being studied in the treatment of other types of cancer. Mitomycin damages the cell’s DNA and may kill cancer cells. It is a type of antineoplastic antibiotic and a type of alkylating agent.",
    "A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin also inhibits RNA and protein synthesis at high concentrations."
  ],
  "abbreviation": "MITC",
  "synonyms": [
    "mitomycin-X",
    "mitomycine C",
    "mitomycin C"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mitomycin/"
}