MLchartDataset catalogue

BMS-275183

Term · Oncology and biomedicine · MLC-T-ONC-012061

An orally available, C-4 methyl carbonate analog of paclitaxel with potential antineoplastic activity. Like paclitaxel, BMS-275183 binds to tubulin and stabilizes microtubules, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and an induction of apoptosis.

Table 1. Record
IdentifierMLC-T-ONC-012061
FieldOncology and biomedicine
ReferencesNational Cancer Institute Thesaurus (CC BY 4.0)
Record as JSON 
{
  "id": "MLC-T-ONC-012061",
  "term": "BMS-275183",
  "field": "Oncology and biomedicine",
  "definition": "An orally available, C-4 methyl carbonate analog of paclitaxel with potential antineoplastic activity. Like paclitaxel, BMS-275183 binds to tubulin and stabilizes microtubules, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and an induction of apoptosis.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bms-275183/"
}

Record 3,698 of 17,721 in Oncology and biomedicine terminology (MLC-0111). Request the full dataset.