brentuximab vedotin

{
  "id": "MLC-T-ONC-001247",
  "term": "brentuximab vedotin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used alone or with other drugs to treat adults with certain types of classic Hodgkin lymphoma, cutaneous or systemic anaplastic large cell lymphoma, large B-cell lymphoma, mycosis fungoides, or peripheral T-cell lymphoma, and with other drugs to treat children aged 2 years and older with certain types of classic Hodgkin lymphoma. It is also being studied in the treatment of other types of cancer. Brentuximab vedotin contains a monoclonal antibody that binds to a protein called CD30, which is found on some lymphoma cells. It also contains an anticancer drug, which may help kill cancer cells. Brentuximab vedotin is a type of antibody-drug conjugate. Also called Adcetris and SGN-35.",
    "An antibody-drug conjugate (ADC) directed against the tumor necrosis factor (TNF) receptor CD30 with potential antineoplastic activity. Brentuximab vedotin is generated by conjugating the chimeric anti-CD30 monoclonal antibody SGN-30 to the cytotoxic agent monomethyl auristatin E (MMAE) via a valine-citrulline peptide linker. Upon administration and internalization by CD30-positive tumor cells, brentuximab vedotin undergoes enzymatic cleavage, releasing MMAE into the cytosol; MMAE binds to tubulin and inhibits tubulin polymerization, which may result in G2/M phase arrest and tumor cell apoptosis. Transiently activated during lymphocyte activation, CD30 (tumor necrosis factor receptor superfamily, member 8;TNFRSF8) may be constitutively expressed in hematologic malignancies including Hodgkin lymphoma and some T-cell non-Hodgkin lymphomas. The linkage system in brentuximab vedotin is highly stable in plasma, resulting in cytotoxic specificity for CD30-positive cells."
  ],
  "abbreviation": "cAC10-vcMMAE",
  "synonyms": [
    "Adcetris",
    "SGN-35",
    "anti-CD30 antibody-drug conjugate SGN-35",
    "anti-CD30 ADC SGN-35",
    "antibody-drug conjugate SGN-35",
    "anti-CD30 monoclonal antibody-MMAE SGN-35",
    "anti-CD30 monoclonal antibody-monomethylauristatin E SGN-35"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/brentuximab-vedotin/"
}