anti-CD30 antibody-drug conjugate SGN-35T

{
  "id": "MLC-T-ONC-010330",
  "term": "anti-CD30 antibody-drug conjugate SGN-35T",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of brentuximab (cAC10), a chimeric immunoglobuin G1 (IgG1) monoclonal antibody directed against the tumor necrosis factor (TNF) receptor CD30 (tumor necrosis factor receptor superfamily, member 8; TNFRSF8) conjugated, via a protease-cleavable tripeptide linker, comprised of D-leucine-alanine-glutamate (DLAE), to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration, anti-CD30 ADC SGN-35T targets, binds to and is internalized by CD30-positive tumor cells. Upon enzymatic cleavage of the cleavable linker, MMAE is released into the cytosol. MMAE binds to tubulin and inhibits tubulin polymerization, which results in G2/M phase arrest and tumor cell apoptosis of CD30-expressing tumor cells. In addition, SGN-35T induces bystander effect in neighboring tumor cells and immunogenic cell death (ICD). CD30 may be constitutively expressed in certain B- and T-cell lymphoma while expression is limited in normal, healthy cells. The linkage system in is highly stable in plasma, resulting in cytotoxic specificity for CD30-positive cells.",
  "synonyms": [
    "ADC SGN-35T",
    "anti-CD30 ADC SGN-35T",
    "cAC10/MMAE antibody-drug conjugate SGN-35T"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd30-antibody-drug-conjugate-sgn-35t/"
}