BTK inhibitor TL-895

{
  "id": "MLC-T-ONC-012152",
  "term": "BTK inhibitor TL-895",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable, selective inhibitor of Bruton's tyrosine kinase (BTK), with potential antineoplastic activity. Upon oral administration, BTK inhibitor TL-895 targets and covalently binds to BTK, thereby preventing its activity. This leads to an inhibition of B cell receptor (BCR) signaling and inhibits cell proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.",
  "synonyms": [
    "Bruton's tyrosine kinase inhibitor M7583"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/btk-inhibitor-tl-895/"
}