bupropion hydrochloride controlled-release

{
  "id": "MLC-T-ONC-012166",
  "term": "bupropion hydrochloride controlled-release",
  "field": "Oncology and biomedicine",
  "definition": "A controlled-release tablet formulation containing the hydrochloride salt of the aminoketone bupropion, with antidepressant activity and for potential use in promoting smoking cessation, improving sexual desire, and improving cancer-related fatigue. Bupropion is a weak blocker of the neuronal uptake of serotonin, dopamine and norepinephrine and is a central nicotinic acetylcholine receptor antagonist. Bupropion may also reduce circulating levels of tumor necrosis factor (TNF) and normalize hypothalamic-pituitary-adrenal (HPA) axis functioning, which is dysregulated in certain cases of cancer-related fatigue. The controlled-release formulation results in a higher concentration of the drug in the body over an extended period, thereby permitting a reduction in the frequency of dosing.",
  "synonyms": [
    "bupropion hydrochloride extended-release",
    "bupropion HCl extended release",
    "bupropion HCl controlled-release"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bupropion-hydrochloride-controlled-release/"
}