Dextromethorphan/bupropion tablet AXS-05

{
  "id": "MLC-T-ONC-013016",
  "term": "Dextromethorphan/bupropion tablet AXS-05",
  "field": "Oncology and biomedicine",
  "definition": "A tablet composed of the non-opioid derivative of morphine dextromethorphan (DM) and the aminoketone bupropion, with potential analgesic, antidepressant and anti-agitation activities. Upon oral administration, the DM component may act as a weak N-methyl-D-aspartate (NMDA) receptor antagonist, a sigma-1 receptor agonist and an inhibitor of the serotonin and norepinephrine transporters, which together may alleviate pain, agitation, anxiety and depression. While the bupropion component acts as a norepinephrine and dopamine reuptake inhibitor and a central nicotinic acetylcholine receptor antagonist, which is beneficial in the treatment of depression. Additionally, bupropion may increase the bioavailability of DM, thus prolonging the therapeutic effects of DM.",
  "synonyms": [
    "DM + BUP"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dextromethorphan-bupropion-tablet-axs-05/"
}