c-Met inhibitor SPH3348

{
  "id": "MLC-T-ONC-012672",
  "term": "c-Met inhibitor SPH3348",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the oncoprotein c-Met (hepatocyte growth factor receptor; HGFR), with potential antineoplastic activity. Upon oral administration, c-Met inhibitor SPH3348 targets and binds to c-Met protein, thereby disrupting c-Met-dependent signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein. c-Met protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/c-met-inhibitor-sph3348/"
}